FoxTrot is one of my all time favorite newspaper comics. I've been reading it since it's debut, originally in my hometown paper the Detroit Free Press, then online via Ucomics and now from the FoxTrot homepage.
Bill Amend, the creator of the strip has always been among the geekiest of comic creators, his affinity for computers and sci-fi has been among the themes of the strip that have kept me a loyal reader.
Amend added this note to his weekly strip
My first newspaper strip drawn and colored entirely in Photoshop using my Wacom Cintiq. Can't wait until I get better at it!
I have no information on how many other strips are created digitally, I imagine it isn't the first, but to move from pen and paper with traditional coloration to a Wacom and Photoshop is great.
Here is the strip from this week

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